A 69-year-old man from Detroit is the second victim.
This comes as the CDC reports that there has been an alarming increase in West Nile cases across the country.
The Michigan Department of Community Health reports that there have been two deaths and 41 cases this season.
Last week, state health officials reported the first death in the state. An elderly woman in Washtenaw County passed away after being hospitalized for West Nile Virus.
For more information on cases and symptoms of West Nile visit http://www.michigan.gov/emergingdiseases/0,4579,7-186-25805--,00.html