From the U.S. Department of Health and Human Services HealthBeat:

The only sure way to avoid a hangover is to not drink so much. But a study indicates it’s possible to increase the chance of a hangover when drinking, or to make one worse – by smoking. Brown University researcher Damaris Rohsenow found this when looking at eight weeks of Web survey data from 113 college students.

Students recorded their smoking and drinking patterns, and symptoms that would indicate a hangover. Their records indicated that smoking on the drinking day was worse than just drinking:

“Those people who smoked more the previous day when they were drinking were more than twice as likely to report any hangover, and report a more severe hangover when they did.”

The report in the Journal of Studies on Alcohol and Drugs was supported by the National Institutes of Health.

Learn more at healthfinder.gov.

Source: http://www.hhs.gov/news/healthbeat/2012/12/20121227a.html